pentobarbital will lessen the extent or outcome of fentanyl transmucosal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to the minimize in fentanyl plasma concentrations, insufficient efficacy or, perhaps, improvement of a withdrawal syndrome in a individual who has created physical dependence to fentanyl.
pentobarbital will reduce the extent or result of paclitaxel protein certain by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.
pentobarbital will minimize the level or influence of vincristine liposomal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Mysterious.
pentobarbital will reduce the level or effect of clozapine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
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pentobarbital will lessen the level or impact of disopyramide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.
pentobarbital will minimize the extent or effect of doxorubicin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will lessen the level or effect of estrogens esterified by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will decrease the extent or effect of diltiazem by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will lower the extent or impact of ethinylestradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. The efficacy of hormonal contraceptives can be decreased. Utilization of a nonhormonal contraceptive is usually recommended.
Withdrawal signs or symptoms may perhaps manifest from abrupt cessation after extended use during the dependent human being and may cause delirium, convulsions, And perhaps Loss of life; barbiturates needs to be withdrawn progressively from any affected person recognized for being using extreme dosage in excess of prolonged periods of time
pentobarbital will decrease the extent or result of theophylline by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will lower the extent or outcome of carvedilol by influencing hepatic enzyme CYP2C9/ten metabolism. Use Caution/Watch.
CYP3A4 inducers might raise the metabolism of clopidogrel to its active metabolite. Monitor patients for opportunity rise read more in antiplatelet effects when CYP3A4 inducers are made use of together with clopidogrel